Interstitial Perfusion Culture with Specific Soluble Factors Inhibits Type I Collagen Production from Human Osteoarthritic Chondrocytes in Clinical-Grade Collagen Sponges.

Articular cartilage has poor healing ability and cartilage injuries often evolve to osteoarthritis.Cell-based strategies aiming to engineer cartilaginous tissue through the combination of biocompatible scaffolds and articular chondrocytes represent an alternative to standard surgical techniques.In this context, perfusion bioreactors have been intro

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Nature and Nurture: Effects of Affective Temperaments on Depressive Symptoms Are Markedly Modified by Stress Exposure

BackgroundLack of proper consideration of the interaction between biological and environmental factors limits our understanding of the development of depression.Our cross-sectional study investigated whether recent stress influences the effect of affective temperaments on depressive symptoms.Methods1015 general population participants completed the

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